Morloc is a novel and powerful strategy for building code libraries and applications. Morloc facilitates the integration of functions from multiple programming languages into a single coherent workflow. The Morloc interface will allow human programmers and emergent AIs to access multi-language code libraries, choose the best functions from any language, and snap them together to create entirely new Morloc programs. The community portal at Morloc.IO will provide a creative hub for programmers from diverse backgrounds to exchange functions and collaborate on multilingual libraries and programs. It will allow businesses to create secure and valuable workflows with open or fee-based access to these libraries.
CamoNano is a novel approach to targeted delivery of gene-editing molecular machinery to cells in living systems using self-assembling “camouflaged” DNA nanoparticles. The central idea of this proposal is to leverage the technology of DNA origami (Rothemund, P. (2006) Folding DNA to create nanoscale shapes and patterns. Nature. 440, 297-302) to fold and mask gene-editing systems (e.g., CRISPR/Cas9) to create virus-sized nanoparticles that are biocompatible, cost-effective, and capable of delivering the gene editor cassettes to specific cells in vivo. The initial proof of principle study is being carried out in zebrafish as a cost effective and highly malleable living system. The results of this proof of principle research will be transferred to mammalian systems in collaboration with academic and industry partners that have already been established to advance the state of the art in the area of eradicating latent virus that cause infectious disease such as HIV, HSV and HPV using CRISPR/Cas9/gRNA cassettes. These cassettes have shown tremendous promise in vivo but are limited by non-targeted delivery mediated by viral vectors. The longer-term grand vision is to create a platform technology for site specifically editing of virtually any genetic locus in vivo and thereby treat or cure a variety of genetic diseases.